Protamine 2 Deficiency Leads to Sperm DNA Damage and Embryo Death in Mice1
نویسندگان
چکیده
منابع مشابه
P-62: Damage to Sperm DNA and Protamine Deficiency Induced by Risperidone in NMRI Mice
Background: Antipsychotic medication use is a common cause of hyperprolactinemia that shown to have adverse effects on male fertility. Risperidone is a combined serotonin/dopamine receptor antagonist that can cause elevations in prolactine level. Its mechanism of cytotoxic effects on testicular germ cells is not fully understood. In the present study we sought to elucidate the impact of risperi...
متن کاملEffect of sperm DNA damage and sperm protamine deficiency on fertilization and embryo development post-ICSI.
The aim of this study was to evaluate the effect of sperm DNA damage and protamine deficiency on fertilization and embryo development post-intracytoplasmic sperm injection (ICSI), and also to assess the effect of protamine deficiency on DNA damage. Semen samples were collected from 28 patients participating in the ICSI programme. Following sperm preparation and ICSI, the remaining processed sem...
متن کاملP-13: Comparison of Sperm Quality, Oxidative Stress, DNA Fragmentation, Protamine Deficiency, and DNA Methylation in Varicocele and Fertile Individuals
s:1993:"Background: There are many approaches that gene expression is controlled in eukaryotes. DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression and lock genes in the "off" position. In addition, sperm DNA damage can correlate with DNA methylation defect. There is evidence that sperm of infertile men contain more DNA damage than fertile men and t...
متن کاملChromomycin A3 Staining Indicates Sperm Protamine Deficiency
Chromomycin A3 binds to DNA and Protamine -deficient spermatozoa look bright yellow,whereas normal spermatozoa appear dull yellow.
متن کاملProtamine 2 precursors, protamine 1/protamine 2 ratio, DNA integrity and other sperm parameters in infertile patients.
BACKGROUND The protamine 1-to-protamine 2 ratio (P1/P2) is altered in the sperm cells of some infertile patients. Also, evidence for increased protamine 2 precursors (pre-P2) in a few patients has been reported. But so far, there have been no studies measuring simultaneously these two variables in a large number of patients. METHODS We measured the P1/P2 ratio and the presence of pre-P2 using...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2003
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.102.015115